Xarelto is a blood thinner and like all blood thinners, its purpose is to prevent or treat the formation of blood clots. Atrial fibrillation (an irregular heartbeat) increases the likelihood of a blood clot forming in the heart. That blood clot can then be transported to the brain via blood vessel where its presence can lead to a stroke. Therefore patients with atrial fibrillation may have a physician prescribe Xarelto to prevent the formation of a blood clot and the occurrence of a stroke. Xarelto is also used to treat patients with deep vein thrombosis (DVT), which can cause blood clots to appear in the lungs (pulmonary embolism). It is also prescribed to reduce the risk of blood clot formation in patients that have recently had hip or knee replacement surgery.

Xarelto comes in 10, 15, and 20 mg tablets. The recommended dosage of Xarelto will depend on what it is being used to treat.

Nonvalvular Atrial Fibrillation

Patients with a CrCl of >50 mL/min should take a 20 mg tablet once daily with the evening meal. Patients with a CrCl of 15 to 50 mL/min should take a 15 mg tablet once daily with the evening meal.

Treatment of DVT or PE

Patients should take a 15 mg tablet twice daily with food for the first 21 days of treatment. But after the first 21 days, a 20 mg tablet should be taken twice daily for the remainder of the treatment.

Reducing the Risk or Recurrence of DVT or PE

It’s recommended that a 20 mg tablet be taken once daily with food.

After Hip or Knee Replacement Surgery

Patients that have had hip replacement surgery may be instructed to take the 10 mg Xarelto pill once daily for 35 days. When prescribed to patients after they have had knee replacement surgery Xarelto should be taken in doses of 10 mg once daily for 12 days.

Cost of Xarelto

Tablet Weight (mg) Quantity Cost ($)
10 30 388.09
100 1,279.62
15 30 388.09
90 1,152.26
100 1,279.62
20 30 388.09
90 1.152.26
100 1.279.26